Manufacturer Supply High Quality Ski-606 CAS 380843-75-4 Bosutinib

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Model NO.: 380843-75-4
• Application: Chronicmyeloid Leukemia
• Product Name: Bosutinib
• Other Name: Ski-606
• CAS No.: 380843-75-4
• Cosmetic Raw Materials: Tianeptine
• Peptide: Amoxicillin
• Transport Package: Bag
• Specification: 10g; 100g; 500g; 1kg
• Trademark: SHUNYI
• Origin: China
• Production Capacity: 100kg/Month

Product Description

Manufacturer Supply High Quality SKI-606 CAS 380843-75-4 Bosutinib
 

Bosutinib is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype.
Product Name: Bosutinib
CAS: 380843-75-4
MF:C26H29Cl2N5O3
MW:530.45
EINECS:700-455-1
MDL No.:MFCD07367846
Melting point:116-120 ºC
Boiling point:649.7±55.0 °C(Predicted)
Density 1.36
vapor pressure 0-0Pa at 20ºC
storage temp. room temp
solubility DMSO: ≥15mg/mL
pka7.63±0.10(Predicted)
form powder
color off-white to light brown
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKeyPICKMQXYAMDEPF-UHFFFAOYSA-N
LogP3.3-4.3 at pH9.5
Surface tension72.4mN/m at 3.6mg/L and 20ºC
Purity: 99% HPLC 
Package: 1g,10g,50g 

 

Items	Specifications	Results
APPEARANCE	WHITE  POWDER	PASS
ASSAY(HPLC)	≥98%	98.5%
Identification: NMR	a:complies with standard(NMR)	PASS
Single impurity	≤1%	1%
Conclusion: Qualified

1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed