Supply Pharmaceutical Raw Material Ambrisentan CAS 177036-94-1

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Model NO.: 177036-94-1
• Application: Pulmonary Hypertension
• Product Name: Ambrisentan
• Other Name: Ambrisentan API
• CAS No.: 177036-94-1
• Type: Powder
• Alpha GPC: Amoxicillin
• Transport Package: Bag; Drum
• Specification: 100g; 500g; 1kg
• Trademark: SHUNYI
• Origin: China
• Production Capacity: 100kg/Month

Product Description

Supply Pharmaceutical Raw Material Ambrisentan CAS 177036-94-1
 

Product Name: Ambrisentan
CAS: 177036-94-1
MF:C22H22N2O4
MW:378.42
EINECS:658-059-9
MDL No.:MFCD09842330
Melting point:>150°C (dec.)
Boiling point:551.1±60.0 °C(Predicted)
Density 1.228±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka0.97±0.10(Predicted)
form Solid
color White to Off-White
Purity: 99% 
Package:  10g;100g;1kg

Ambrisentan is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors.

Chemical and Physical Properties
Appearance	Light Tan powder
Solubility	White to off-white powder
Quality standard	CHINA GMP
Application
Drug Indication/Application/Use	Ambrisentan is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening.
Formulations/Preparations	antihypertensive endothelin receptor antagonist

 






1.Preferentially DHL, FedEX or TNT for quantity less than 50kg, air shipping for 100kg above, sea shipping for quantity over 500kg.
2.For customers from Russia,Mexico,Turkey,Solvenia,Romania,etc,before placing an order,please kindly confirm if you can make clearance when goods reach your customs.

Shipping Terms
By Express	By Air	By Sea
Suitable for under 50kg Fast:3-4 days High cost Door to door service Easy to pick up the goods	Suitable for more than 50kg Fast:3-4 days High cost Airport to airport Professional broker needed	Suitable for more than 500kg Slow:15-30 days Low cost Port to port Professional broker needed