| Certification: | RoHS, BRC, ISO, FDA, HACCP |
|---|---|
| Assay Method: | HPLC |
| Application Form: | Injection, Lotion, Suppository, Paste, Tablet, Capsule |
| Application: | Food, Health Care Products, Medicine |
| State: | Powder |
| Extract Source: | Sophora Japonica |
| Samples: |
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| Customization: |
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Hesperidin
is a major flavonoid found in lemons and sweet oranges as well as in some other fruits and vegetables, and various polyherbal formulations. Hesperetin is a metabolite of hesperidin which has better bioavailability. Hesperidin exhibits several pharmacological actions such as antihyperlipidemic, cardioprotective, antihypertensive, antidiabetic activities, which are mainly attributed to an antioxidant defense mechanism and suppression of pro-inflammatory cytokine production. Various randomized crossover trials have shown the beneficial effects of hesperidin, which mainly results from anti-inflammatory and anti-atherogenic actions. Acute oral toxicity studies have shown that LD50 of hesperidin is more than 2000 mg/kg, while subacute and subchronic toxicity studies have shown that the no-observed-adverse-effect level is more than 2000 mg/kg, indicating the safety of hesperidin in herbal formulations.
Sources
Citrus Fruits
Oranges
Tangerines
Lemons
Limes
Citrus fruit hybrids
Sun-dried tangerine peels
Health Benefits of Hesperidin
Likely Effective for:
1) Chronic Venous Insufficiency
Chronic venous insufficiency, commonly known as varicose veins, is a condition in which the walls and valves in the veins fail to work. As a result, the blood cannot be returned to the heart and pools in the legs, increasing blood pressure until the smallest blood vessels (capillaries) burst. This can cause local inflammation and tissue damage, swelling, and even ulcer formation
Chronic venous insufficiency can generally be improved with non-invasive procedures such as wearing compression stockings, avoiding tight clothes, exercising more, losing weight, elevating the legs, and avoiding long periods of sitting or standing
In more severe cases, the doctor may suggest procedures such as sclerotherapy, laser treatments, catheter-assisted procedures, vein stripping, phlebectomy, or endoscopic vein surgery
Daflon is a purified citrus flavonoid mixture containing 10% hesperidin and 90% diosmin. Daflon administration inhibits the inflammatory response and free radical production in the vessels, reducing swelling and protecting their tissues
Six clinical trials on almost 500 people with chronic venous insufficiency found that Daflon improved capillary resistance, ulcer healing, vein elasticity, and blood flow
Another mixture with hesperidin, vitamin C, and butcher's broom (Ruscus aculeatus) extract (Cyclo 3 Fort) also improved chronic venous insufficiency symptoms in a meta-analysis of 25 studies and over 10,000 people
All in all, the existing evidence suggests that both Daflon and Cyclo 3 Fort improve chronic venous insufficiency symptoms. Note, however, that neither of them is approved by the FDA for this condition. Consult your doctor before taking hesperidin-containing supplements for chronic venous insufficiency.
2) Hemorrhoids
Hemorrhoids are swollen veins in the anus and rectum, similar to varicose veins. Hemorrhoids are often relieved by eating high-fiber foods, applying over-the-counter ointments or suppositories, regularly soaking them in warm water, and taking oral painkillers. Hemorrhoids with persistent pain or bleeding may be treated with minimally invasive procedures such as rubber band ligation, sclerotherapy, or coagulation techniques. Severe cases that don't respond to these procedures may require surgical removal or stapling
A flavonoid mixture with 10% hesperidin and 90% diosmin (Daflon) improved hemorrhoid symptoms such as pain, bleeding, heaviness, itching, and anal discharge in clinical trials on over 700 people. Daflon also reduced pain and bleeding after the surgical removal and stapling of hemorrhoids in 2 trials on almost 300 people
Similarly, the mixture of hesperidin with other flavonoids (such as diosmin, troxerutin, rutin, and quercetin) reduced pain, swelling, bleeding, and painkiller use in 2 clinical trials on over 200 people
As in the previous case, evidence suggests that Daflon and other hesperidin-containing flavonoid mixtures may improve hemorrhoid symptoms, but none of them is approved for this condition. You may discuss with your doctor if these supplements may help in your case.
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Product name
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Citrus Aurantium Extract
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Botanical source
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Citrus aurantium L.
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Specification
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hesperidin 95%
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Appearance
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Yellow powder
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Odor &Taste
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Characteristic
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Particle size
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80 mesh
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Loss on drying
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≤5.0%
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Ash (3h at 600ºC)
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≤5.0%
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Heavy Metal
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≤10ppm
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As
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≤2ppm
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Pb
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≤2ppm
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Cd
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≤1ppm
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Hg
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≤0.1ppm
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Total of bacteria
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≤1000cfu/g
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Fungi
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≤100cfu/g
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Salmonella
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Negative
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E.Coli
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Negative
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Staphylococcus aureus
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Negative
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Certificate
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HALAL/ KOSHER
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